High Cotton is a subdivision in Oxford, Mississippi. Oxford is a city in, and the county seat of, Lafayette County, Mississippi, United States. Founded in 1837, it was named after the British university city of Oxford in hopes of having the state university located there, which it did successfully attract. Oxford is the home of the University of Mississippi, founded in 1848, also commonly known as “Ole Miss”, although the university is officially located in University, Mississippi. Oxford has been named by USA Today as one of the top six college towns in the nation. It is included in The Best 100 Small Towns in America. Lafayette County consistently leads the state rankings in the lowest unemployment rate per quarter. Oxford City Schools are ranked as “Star” schools, the highest ranking available, and Lafayette County school systems are consistently ranked as “5-star” systems.
The courthouse square, called “The Square”, is the geographic and cultural center of the city. In addition to the historic Lafayette County Courthouse, the Square is known for an abundance of locally owned restaurants, specialty boutiques, and professional offices, along with Oxford City Hall. The J. E. Neilson Co., located on the southeast corner of the square is the South’s oldest documented store. Founded as a trading post in 1839, Neilson’s continues to anchor the Oxford square. Square Books, a local bookstore founded in 1979, is consistently ranked among the best independent bookstores in the country. A sister store, Off Square Books, which is several doors down the street to the east, deals in used and remainder books and is the venue for a radio show called Thacker Mountain Radio, with host Jim Dees, that is broadcast state-wide on Mississippi Public Broadcasting.
The City of Oxford is served by the Oxford School District and by two private schools, Oxford University School and Regents School. Regents is located just outside the city limits in the College Hill community. Oxford is partially the home of the main campus of the University of Mississippi, known as “Ole Miss”, (the official location is University, Mississippi) and of the Lafayette-Yalobusha Center of Northwest Mississippi Community College. The Baptist Memorial Hospital – North Mississippi, located in Oxford provides comprehensive health care services for Oxford and the surrounding area, supported by a growing number of physicians, clinics and support facilities. The North Mississippi Regional Center, a state-licensed Intermediate Care Facility for the Mentally Retarded, is located in Oxford. Oxford is home to the National Center for Natural Products Research at the University of Mississippi’s School of Pharmacy. The Center is the only facility in the United States that is federally licensed to cultivate marijuana for scientific research, and for distribution to patients who are allowed marijuana for medical purposes.